HYPOMAGNESAEMIA AND HYPOCALCAEMIA THE MAJOR MISSED OUT CLINICAL CONDITION IN THE MANAGEMENT OF DIABETES

Authors

  • Divya S
  • Fahima Sheerin SMH 1Department of Medical Laboratory Technology, Loyola College, Nungambakkam Chennai, India
  • Chindhiha S 1Department of Medical Laboratory Technology, Loyola College, Nungambakkam Chennai, India
  • Suganthi M Post Doctoral Fellow, Centre for Biotechnology, Anna University, Guindy Chennai, India
  • Sherafin Vincy Department of Medical Laboratory Technology, Loyola College, Nungambakkam Chennai, India
  • Chandrasekar M Department of Medical Laboratory Technology, Loyola College, Nungambakkam Chennai, India
  • Dr Selvakumar Kandaswamy The Tamilnadu MGR Medical University

DOI:

https://doi.org/10.31878/ijcbr.2021.72.04

Keywords:

Magnesium, calcium, insulin secretion, uncontrolled diabetes, electrolytes

Abstract

Magnesium (Mg) and Calcium (Ca) is one of the essential factors for the insulin to get released from the pancreatic cell. To evaluate the relation of hypomagnesemia and hypocalcaemia in the glycaemic control and to analyse the importance of both Mg and Ca in the insulin secretion mechanism. The study was conducted in the laboratory department, Billroth hospitals. A total of 239 individuals were selected for this study, HbA1c level, serum magnesium and calcium were assessed for all the individuals and in addition to this serum electrolytes were also checked. Out of 239 individuals, 79 were found out as uncontrolled diabetic by calculating HbA1c as a gold standard, males are higher in ratio compared to female. By studying serum magnesium and calcium level, hypocalcaemia is present in more individuals and females (31%) are much prone to both than males (20%). The different correlation was also analysed for hypomagnesemia and hypocalcaemia. The electrolytes like sodium (Na) and potassium (K) was analysed, females are highly affected by electrolyte imbalance but in hypomagnesemia diabetic individuals the males are high in electrolyte imbalance. Since Mg and Ca plays a vital role in insulin synthesis, secretion, repair, and the alteration, along with the hypoglycaemic agents the supplementation of magnesium or calcium could be suggested via, dietary or drug supplements. In addition to this, regular monitoring of electrolytes is essential to maintain fluid balance.

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Author Biographies

Fahima Sheerin SMH, 1Department of Medical Laboratory Technology, Loyola College, Nungambakkam Chennai, India

 

 

Chindhiha S, 1Department of Medical Laboratory Technology, Loyola College, Nungambakkam Chennai, India

 

 

Suganthi M, Post Doctoral Fellow, Centre for Biotechnology, Anna University, Guindy Chennai, India

 

 

Sherafin Vincy, Department of Medical Laboratory Technology, Loyola College, Nungambakkam Chennai, India

 

 

Chandrasekar M, Department of Medical Laboratory Technology, Loyola College, Nungambakkam Chennai, India

 

 

References

1. McPhee, S.J. and M.A. Papadakis, Diabetes mellitus and hyperlycemia. In: Masharani U, editor. Current medical diagnosis and treatment. 49th ed. USA: Churchill Livingstone The McGraw-Hill Companies, 2010, 1079-1133.
2. Diabetes blue circle symbol. International diabetes federation. Archived from the original, 2006, 2007.
3. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998 Jul;15(7):539-53.
4. Roden, M.; Petersen, K.; Shulman, G. Insulin Resistance in Type 2 Diabetes. In Textbook of Diabetes, 5th ed.; Holt, R.I., Cockram, C., Flyvbjerg, A., Goldstein, B.J., Eds.; John Wiley & Sons: New York City, NY, USA, 2017; 174–186.
5. Xu H, Li X, Adams H, Kubena K, Guo S. Etiology of Metabolic Syndrome and Dietary Intervention. Int J Mol Sci. 2018 Dec 31;20(1).
6. Muhammed Khalid Shaikh, Bikha Ram Devrajani, Aftab Ahmed Soomro, Syed Zulfiquar Ali Shah, Tarachand Devrajani and Thanver Das, Hypomagnesemia in Patients with Diabetes mellitus, Department of Medicine, Liaquat University of Medical and Health Sciences Jamshoro, Hyderabad (LUMHS), Pakistan, World Applied Sciences Journal 12 (10): 1803-1806, 2011.
7. Liamis G, Liberopoulos E, Barkas F, Elisaf M. Diabetes mellitus and electrolyte disorders. World J Clin Cases. 2014 Oct 16;2(10):488-96.
8. Guyton A, Hall J. Textbook of Medical Physiology; Elsevier Saunders: Philadelphia, PA, USA. 2006; 348-381.
9. Wang JL, Shaw NS, Yeh HY, Kao MD. Magnesium status and association with diabetes in the Taiwanese elderly. Asia Pac J Clin Nutr. 2005;14(3):263-9.
10. Bertinato J, Wu Xiao C, Ratnayake WM, Fernandez L, Lavergne C, Wood C, Swist E. Lower serum magnesium concentration is associated with diabetes, insulin resistance, and obesity in South Asian and white Canadian women but not men. Food Nutr Res. 2015 May 5; 59:25974.
11. De Baaij JH, Hoenderop JG, Bindels RJ. Magnesium in man: implications for health and disease. Physiol Rev. 2015 Jan;95(1):1-46.
12. Pham PC, Pham PM, Pham PA, Pham SV, Pham HV, Miller JM, Yanagawa N, Pham PT. Lower serum magnesium levels are associated with more rapid decline of renal function in patients with diabetes mellitus type 2. Clin Nephrol. 2005 Jun;63(6):429-36.
13. Nair A, Hocher B, Pfab T, Konrad M, van Zeeland F, Bindels R, et al. Two Genetic Variants of TRPM6 Increase Risk for Hypomagnesemia Associated with Diabetes Mellitus Type 2. Biophysic J 2011;100(3):87a.
14. Cruz KJ, de Oliveira AR, Pinto DP, Morais JB, Lima Fda S, Colli C, Torres-Leal FL, Marreiro Ddo N. Influence of magnesium on insulin resistance in obese women. Biol Trace Elem Res. 2014 Sep;160(3):305-10.
15. Guerrero-Romero F, Rodríguez-Morán M. Magnesium improves the beta-cell function to compensate variation of insulin sensitivity: double-blind, randomized clinical trial. Eur J Clin Invest. 2011 Apr;41(4):405-10.
16. Williams PF, Caterson ID, Cooney GJ, Zilkens RR, Turtle JR. High affinity insulin binding and insulin receptor-effector coupling: modulation by Ca2+. Cell Calcium. 1990 Sep;11(8):547-56.
17. Cooper MS, Gittoes NJ. Diagnosis and management of hypocalcaemia. BMJ. 2008 Jun 7;336(7656):1298-302.
18. Clapham DE. Calcium signaling. Cell. 2007 Dec 14;131(6):1047-58.
19. Henquin JC, Ravier MA, Nenquin M, Jonas JC, Gilon P. Hierarchy of the beta-cell signals controlling insulin secretion. Eur J Clin Invest. 2003 Sep;33(9):742-50.
20. Ahn C, An BS, Jeung EB. Streptozotocin induces endoplasmic reticulum stress and apoptosis via disruption of calcium homeostasis in mouse pancreas. Mol Cell Endocrinol. 2015 Sep 5; 412:302-8.
21. Ojuka EO. Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle. Proc Nutr Soc. 2004 May;63(2):275-8.
22. Kostov K. Effects of Magnesium Deficiency on Mechanisms of Insulin Resistance in Type 2 Diabetes: Focusing on the Processes of Insulin Secretion and Signaling. Int J Mol Sci. 2019 Mar 18;20(6).
23. Kao WH, Folsom AR, Nieto FJ, Mo JP, Watson RL, Brancati FL. Serum and dietary magnesium and the risk for type 2 diabetes mellitus: The Atherosclerosis Risk in Communities Study. Arch Intern Med. 1999 Oct 11;159(18):2151-9.
24. Noor MM, Nazir Q, Khan TM, Gillani S, Abbasi MA, Rauf A, Qureshi ZU. Association Between Low Serum Magnesium Level and Type 2 Diabetes Mellitus in Abbottabad. J Ayub Med Coll Abbottabad. 2019 Apr-Jun;31(2):226-229.
25. Pham PC, Pham PM, Pham SV, Miller JM, Pham PT. Hypomagnesemia in patients with type 2 diabetes. Clin J Am Soc Nephrol. 2007 Mar;2(2):366-73.
26. Khan RN, Saba F, Kausar SF, Siddiqui MH. Pattern of electrolyte imbalance in Type 2 diabetes patients: Experience from a tertiary care hospital. Pak J Med Sci. 2019;35(3):797-801.
27. Naresh Kumar Jha, Study of lipid profile & electrolyte levels in diabetes, Department of Biochemistry, Shree Narayan Medical Institute & Hospital, Saharsa, Bihar, India, International Journal of Medical and Health Research, volume 3, 146-148, 2017.

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Published

2021-05-04

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Original Research Articles