International Journal of Clinical and Biomedical Research https://www.sumathipublications.com/index.php/ijcbr <p style="text-align: center;"><strong>ISSN: 2395-0471 (Online),&nbsp;</strong><strong>ISSN: 2521-0394 (Print).</strong></p> <p style="text-align: center;"><strong>Journal indexed in following major databases; Logos are embedded with respective links. Go to Indexed in page for more indexing information</strong></p> <hr> <p><a href="https://journals.indexcopernicus.com/search/journal/issue?issueId=all&amp;journalId=32442" target="_blank" rel="noopener"><img src="/public/site/images/admin/copernicus.jpg" alt="" width="115" height="32"></a> <a href="https://www.base-search.net/Search/Results?q=dccoll:ftsumathipubl&amp;refid=dcrecen" target="_blank" rel="noopener"><img src="/public/site/images/admin/base.png" alt="" width="74" height="35"></a> &nbsp;<a href="https://scholar.google.co.in/scholar?start=0&amp;q=2395-0471&amp;hl=en&amp;as_sdt=0,5" target="_blank" rel="noopener"><img src="/public/site/images/admin/GoogleScholar1.png" alt="" width="74" height="28"></a> <a href="http://www.worldcat.org/search?q=ijcbr&amp;qt=results_page" target="_blank" rel="noopener"><img src="/public/site/images/admin/logo_wcmasthead_en1.png" alt="" width="102" height="32"></a> <a href="http://index.pkp.sfu.ca/index.php/browse/index/4035" target="_blank" rel="noopener"><img src="/public/site/images/admin/pkp-index-301.png" alt=""></a> <a href="http://www.sherpa.ac.uk/romeo/search.php?source=journal&amp;sourceid=30542&amp;la=en&amp;fIDnum=|&amp;mode=simple" target="_blank" rel="noopener"><img src="/public/site/images/admin/sherparomeo-home.jpg" alt=""></a> <a href="http://imsear.searo.who.int/handle/123456789/170455?subject_page=1" target="_blank" rel="noopener"><img src="/public/site/images/admin/rsz_21rsz_1rsz_imsear.png" alt="" width="141" height="30"></a></p> <hr> <p>International Journal of Clinical and Biomedical Research provides an outlet for research scientists in areas of Health Sciences. IJCBR is open access, online &amp; print, peer-reviewed international journal with a primary objective to provide research and applications related to all the health sciences:</p> <p>All branches of Biomedical Sciences,</p> <ul> <li class="show">Biology,</li> <li class="show">Dentistry,</li> <li class="show">Medical Education,</li> <li class="show">Physiotherapy,</li> <li class="show">Pharmacy, and Nursing.</li> </ul> <p>Submitted papers must be in technical English, suitable for scientific publication. All articles have to be original articles that have not been published elsewhere or are being considered for publication in other journals. All articles submitted will be peer-reviewed by experts. Receipt of the manuscript will be acknowledged by email. Every effort will be made to complete the review process within 3 weeks and communicated to the corresponding author. Papers should be submitted electronically on the journal's website. The Editorial Board will strive for the quality of the journal and will also index the journal in various indexing bodies and the information will be updated on the journal website from time to time. We welcome all your submissions. I hope you will consider IJCBR for your next submission. If any further information is required please mail to:</p> <p>&nbsp;<a href="mailto:editor.ijcbr@gmail.com">Editor</a> and/or <a href="mailto:journaloffice@sumathipublications.com">Journal Office</a>.</p> <p>The journal accepts manuscripts in the following forms:</p> <ul> <li class="show">Original research articles</li> <li class="show">Reviews</li> <li class="show">Case reports</li> <li class="show">Short communications</li> <li class="show">Letters to editor</li> <li class="show">Discussion papers</li> <li class="show">Clinical Experience</li> <li class="show">Clinicopathological correlation Book reviews and</li> <li class="show">"How to do it" type articles describing new methods or procedures.</li> </ul> <p>Kind regards,</p> <p>IJCBR Editorial Team.</p> Sumathi Publications en-US International Journal of Clinical and Biomedical Research 2521-0394 <p>The journal <strong>allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions</strong>.</p> <p>The submitted papers are assumed to contain no proprietary material unprotected by patent or patent application; responsibility for technical content and for protection of proprietary material rests solely with the author(s) and their organizations and is not the responsibility of the journal. The main (first/corresponding) author is responsible for ensuring that the article has been seen and approved by all the other authors. It is the responsibility of the author to obtain all necessary copyright release permissions for the use of any copyrighted materials in the manuscript prior to the submission.</p> <p><strong>What are my rights as an author?</strong><br>It is important to check the policy for the journal to which you are submitting or publishing to establish your rights as<br>Author. Journal's standard policies allow the following re-use rights:</p> <ul> <li class="show">The journal allows the author(s) to hold the copyright without restrictions.</li> <li class="show">The journal allows the author(s) to obtain publishing rights without restrictions.</li> <li class="show">You may do whatever you wish with the version of the article you submitted to the journal.</li> <li class="show">Once the article has been accepted for publication, you may post the accepted version of the article on your own personal website, your department's website or the repository of your institution without any restrictions.</li> <li class="show">You may not post the accepted version of the article in any repository other than those listed above (i.e. you may not deposit in the repository of another institution or a subject-matter repository) until 12 months after publication of the article in the journal.</li> <li class="show">You may use the published article for your own teaching needs or to supply on an individual basis to research colleagues, provided that such supply is not for commercial purposes.</li> </ul> Perception of Tuberculosis Treatment in Tribal area of Akole Block of Ahmednagar, Maharashtra https://www.sumathipublications.com/index.php/ijcbr/article/view/392 <p>Introduction: The family’s knowledge and perception of any disease are essential conditions to formulate effective health policies to combat the disease. The tribal populations of India are likely to live discrete hard to reach geographic areas with their common cultural and socio-religious beliefs which are quite different from the general population. The present study was aimed to evaluate attitude with regards to the treatment of tuberculosis among the tribal community in Akole block of Ahmednagar District, Maharashtra. Methods: This was a qualitative cross-sectional study conducted in the tribal community. The study participants were subjected to a well-structured questionnaire which contained questions about the demographics and attitude of the patients concerning tuberculosis. Results: Twenty patients were included in the study, of which 12 (60%) were males while 8 (40%) were females. Majority of study participants opined that the treatment of tuberculosis should be free (19, 95%), agreed that they should disclose their illness to other people (17, 85%), were scared (12, 60%). Only 6 participants felt of being discriminated in the community. It was regarded by most of the participants that pregnant women won’t be affected by tuberculosis (15, 85%). Most of the study participants approached Private practitioner (11, 55%) and Public health care centre (8, 40%) initially, but preferred treatment from Governmental facility (18, 90%) upon the private facility (2, 10%). Conclusion: There has been a change in attitude and treatment-seeking behaviour of people of Tribal community with regards to tuberculosis. The community needs to be educated with regards to tuberculosis to alleviate fear and eliminate misconceptions. Control of TB in tribal areas continues to face some significant challenges.</p> Afwan Khan Swanand Tilekar Sunil Thitame Somasundaram Konduri ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2020-10-29 2020-10-29 1 4 10.31878/ijcbr.2020.64.01 EFFECTS OF COGNITIVE BEHAVIORAL THERAPY (CBT) AND MEDITATION IN CHRONIC LOW BACK PAIN https://www.sumathipublications.com/index.php/ijcbr/article/view/385 <p><strong><em>Abstract –&nbsp;&nbsp; </em></strong></p> <p><em>Context</em>: <strong>Chronic low back pain (CLBP)</strong> is a highly prevalent and often disabling condition among adults. <strong>Meditation</strong>&nbsp;is a practice which uses a technique like mindfulness, or focusing their mind on a particular thought, activity - to train awareness, achieve a mentally clear and emotionally calm state. <strong>Cognitive – behavioral therapy (CBT)</strong> is a form of psychotherapy that has been documented to be effective in treating depression, chronic pain and other mental disorders.</p> <p><em>Aim:</em>&nbsp; To compare the effects of both, CBT and Meditation on pain management in CLBP.</p> <p><em>Method</em>: 27 patients with CLBP between the age group of 36-50 yrs were selected. They were divided into 3 groups. A 4 week intervention of conventional physiotherapeutic exercises, Meditation and CBT was given. Oswestry Low Back Pain Disability Questionnaire and Numerical Pain Rating Scale were used as outcome measures.</p> <p><em>Results</em>: Our study shows significant results pre and post all interventions, but no significant difference can be seen when the three interventions are compared to each other (with p&lt;0.05)</p> <p><em>Conclusion</em>: On the basis of the result obtained, we can say that all three interventions have a positive effect in pain reduction in CLBP.Statistically, no intervention has a better effect over others. But clinically meditation group performed better.</p> Manali Bora Ranade Parag S ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2020-10-29 2020-10-29 5 8 10.31878/ijcbr.2020.64.02 True and Pseudo Cholinesterase levels in short and long-term of pesticides exposures https://www.sumathipublications.com/index.php/ijcbr/article/view/367 <p>The present study is aimed to study and analyze the true and pseudo Cholinesterase levels in the subjects exposed to pesticides during short term by intentional or accidental intake and long term exposure due to their occupation were studied at Department of Biochemistry, SVS medical college and hospital mahbubnagar district. Whole blood cholinesterase levels and Pseudo cholinesterase levels were estimated. 150 people were taken as controls who had no medical illness and a total number of 300 cases of pesticide poisoning were selected, aged between 20 to 55 years, which consist of 150 acute poisoning and 150 chronic poisoning subjects in Mahbubnagar district, were taken as case study, the detailed case history and the type of organophosphorus pesticide taken were recorded. Mean and standard deviation (S.D) of all variables were calculated and compared with those of controls. Statistical significance was assessed and P-value &lt;0.05 were considered significant.</p> <p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; During acute poisoning the mean value of Whole blood cholinesterase/True cholinesterase (U / L) in acute poisoning cases on first day was 1.267± 0.612 on 3<sup>th</sup> day was 1.651±0.647, on 7<sup>th</sup> day was 2.221±0.684 and at the end of 6 months was 3.970±0.404.The difference between the study group and control group (4.0 ± 0.39) was found to be statistically significant in1st, 3rd, 7th day but not significant at the end of 6 months. The mean value of serum cholinesterase/pseudo cholinesterase (U/L) in acute poisoning cases on first day was 2213.05 ± 1749.81, on 3<sup>th</sup> day was 2862.3 ± 2025.6, on 7<sup>th</sup> day was 4008.4 ± 2355.9 and at the end of 6 months was 7708.34 ± 880.72.The difference between the study group and control group (7991.97 ± 1276.5) was found to be statistically significant in1st, 3rd, 7th day but not significant at the end of 6 months.</p> <p>During chronic poisoning (exposure) the mean value of Whole blood cholinesterase (U/L) in controls is 4.0 ± 0.39 as compared to 3.019 ± 0.848 in cases of chronic poisoning. The difference between the study group and control group was found to be statistically significant. The mean value of serum cholinesterase/pseudo cholinesterase (U/L) in controls was 7991.97 ± 1276.5 as compared to 6214 ± 1189 in cases of chronic poisoning. The difference between the study group and control group was found to be statistically significant.</p> Mohammed Abdul Rahman Raghunatha Rao D Vasantha L ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2020-10-29 2020-10-29 9 12 10.31878/ijcbr.2020.64.03 EFFECT OF 5 WEEKS RADIATION THERAPY ON PULMONARY FUNCTIONS IN BREAST CANCER PATIENTS: A PILOT STUDY https://www.sumathipublications.com/index.php/ijcbr/article/view/386 <p><strong>ABSTRACT:</strong></p> <p><strong>BACKGROUND:</strong> The lung has a very little regenerative capacity; it cannot tolerate long doses of radiation. The critical injuries that eventually lead to impaired ventilation and diffusion capacity are related to total dose, its fractionation, and volume of lung irradiated. The absorption of ionizing radiation causes immediate subcellular and cellular damage while its gross morphological expression in terms of tissue injury.</p> <p><strong>Aim of study: </strong>To observe the effect of 5 weeks of Radiation Therapy on Pulmonary Functions in breast cancer patients <strong>Methodology</strong>: The study was carried out on ten subjects ranging in the age group of 35-65 years where PFT parameters were recorded initially and at the end of every week for five weeks. Then parameters were compared pre radiation and every week after the radiation therapy for five weeks.</p> <p><strong>RESULT</strong>: Data was analyzed in terms of the mean difference. Statistically, there were no significant changes seen in the PFT parameter values that are pre- radiation and post-radiation every week for five weeks and the p values obtained were for following parameters 1) FVC – 0.487 2) FEV1 – 0.863 3) FEV1/FVC – 0.487 4) FEF<sub>25-75% </sub>- 5) PEFR- .</p> <p><strong>CONCLUSION: </strong>There were no significant changes that were found in the parameters of the pulmonary function test. Changes in lung volume and capacities are expected after Radiation therapy that is risk of damaging pulmonary parenchyma and losing type 2 pneumocytes but patient never present changes due to compensation in relation to healthy changes which did not receive radiation.</p> <p><strong>KEY WORDS</strong>: Breast Cancer,Radiation Therapy,Pulmonary Function Test</p> Nikita Anil Shastri Abhijit D Diwate Arijit Kumar Das Reshma Shete ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2020-10-29 2020-10-29 13 17 10.31878/ijcbr.2020.64.04 Valuation of stress patterns in the peri implant bone of non-parallel implants supporting a long-cantilevered prosthesis: a 3D finite element analysis https://www.sumathipublications.com/index.php/ijcbr/article/view/394 <p>The treatment modality for completely edentulous arches has shifted from complete dentures to dental implants during the last 15-20 years. Tilting of implants has reduced the concern of resorbed posterior ridges in completely edentulous patients with “All-on-four” and “All-on-six” concept of dental implants. The purpose of this study is to compare the biomechanical behaviour of the “All-on-four”, “All-on-six” models with tilted distal implants at different angulations of 30 and 45 ° with four parallel placed implant-supported fixed prosthesis, and six parallel placed implant-supported fixed prosthesis models as controls using three-dimensional finite element analysis. The results showed that in all the models, in cancellous bone, cortical bone, implant and prosthesis – “All-on-four” model with distal implants tilted at an angulation of 30° showed stress values less than or equivalent to all the other models except on the implant in the presence of cantilever and on prosthesis during full mouth biting load where maximum stresses were observed. The study shows that All-on-four concept with tilted distal implants at an angulation of 30° showed stress values favourable for the rehabilitation of completely edentulous maxilla, but the presence of cantilever remains an area of concern.</p> Mohammed Abusaad Siddiqui Sudheer N Dulala Vikram Raj Aditi Chintamani Sabnis Alluru Amrutesh Anurag Lahoti ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2020-10-29 2020-10-29 18 24 10.31878/ijcbr.2020.64.05 Total body irradiation in a case of thalassemia major with source to axis distance based planning: A case report https://www.sumathipublications.com/index.php/ijcbr/article/view/393 <p>Background: The use of total body radiation (TBI) before hematopoietic stem cell transplantation (HSCT) would increase the engraftment without transplant-related morbidity or mortality among Thalassemia major (TM) cases. Case presentation: A 2-year-old female child, diagnosed with TM was scheduled for haploidentical allogenic transplant-based protocol, and after that, based on protocol she was scheduled to undergo a single session of TBI as a conditioning regimen before haploidentical allogenic hematopoietic stem cell tranplant. A total dose of 4 Gy was administered.. The incidence of graft failure was reduced as TBI was used before allogeneic stem cell transplantation. TBI provided a uniform dose of radiation to the entire body, penetrating areas such as the central nervous system (CNS) and testes. Conclusion: Total Body Irradiation with the SAD technique is the most effective way of treatment. As it is comfortable for the patient to undergo, easily reproducible, and it helps to achieve a uniform dose distribution.</p> Mayuresh D. Virkar Rajkumar Chauhan Pranav Chadha Kaustav Talapatra Reuben Jake Rodrigues Amrita Shrivastava Santanu Sen Sameer Tulpule ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2020-10-29 2020-10-29 25 28 10.31878/ijcbr.2020.64.06