International Journal of Clinical and Biomedical Research https://www.sumathipublications.com/index.php/ijcbr <p style="text-align: center;"><strong>ISSN: 2395-0471 (Online), </strong><strong>ISSN: 2521-0394 (Print).</strong></p> <p style="text-align: center;"><strong>Journal indexed in following major databases; Logos are embedded with respective links. Go to the Indexed in page for more indexing information</strong></p> <hr /> <p><a href="https://journals.indexcopernicus.com/search/journal/issue?issueId=all&amp;journalId=32442" target="_blank" rel="noopener"><img src="https://www.sumathipublications.com/public/site/images/admin/copernicus.jpg" alt="" width="115" height="32" /></a><a href="https://www.base-search.net/Search/Results?q=dccoll:ftsumathipubl&amp;refid=dcrecen" target="_blank" rel="noopener"><img src="https://www.sumathipublications.com/public/site/images/admin/base.png" alt="" width="74" height="35" /></a> <a href="https://scholar.google.co.in/scholar?start=0&amp;q=2395-0471&amp;hl=en&amp;as_sdt=0,5" target="_blank" rel="noopener"><img src="https://www.sumathipublications.com/public/site/images/admin/GoogleScholar1.png" alt="" width="74" height="28" /></a><a href="http://www.worldcat.org/search?q=ijcbr&amp;qt=results_page" target="_blank" rel="noopener"><img src="https://www.sumathipublications.com/public/site/images/admin/logo_wcmasthead_en1.png" alt="" width="102" height="32" /></a><a href="http://index.pkp.sfu.ca/index.php/browse/index/4035" target="_blank" rel="noopener"><img src="https://www.sumathipublications.com/public/site/images/admin/pkp-index-301.png" alt="" /></a><a href="http://www.sherpa.ac.uk/romeo/search.php?source=journal&amp;sourceid=30542&amp;la=en&amp;fIDnum=|&amp;mode=simple" target="_blank" rel="noopener"><img src="https://www.sumathipublications.com/public/site/images/admin/sherparomeo-home.jpg" alt="" /></a><a href="http://imsear.searo.who.int/handle/123456789/170455?subject_page=1" target="_blank" rel="noopener"><img src="https://www.sumathipublications.com/public/site/images/admin/rsz_21rsz_1rsz_imsear.png" alt="" width="141" height="30" /></a></p> <hr /> <p>International Journal of Clinical and Biomedical Research provides an outlet for research scientists in areas of Health Sciences. IJCBR is open access, online &amp; print, peer-reviewed international journal with a primary objective to provide research and applications related to all the health sciences:</p> <p>All branches of Biomedical Sciences,</p> <ul> <li class="show">Biology,</li> <li class="show">Dentistry,</li> <li class="show">Medical Education,</li> <li class="show">Physiotherapy,</li> <li class="show">Pharmacy, and Nursing.</li> </ul> <p>Submitted papers must be in technical English, suitable for scientific publication. All articles have to be original articles that have not been published elsewhere or are being considered for publication in other journals. All articles submitted will be peer-reviewed by experts. Receipt of the manuscript will be acknowledged by email. Every effort will be made to complete the review process within 3 weeks and communicated to the corresponding author. Papers should be submitted electronically on the journal's website. The Editorial Board will strive for the quality of the journal and will also index the journal in various indexing bodies and the information will be updated on the journal website from time to time. We welcome all your submissions. I hope you will consider IJCBR for your next submission. If any further information is required please mail to:</p> <p> <a href="http://localhost/sppp/index.php/index/admin/wizard/2/mailto:editor.ijcbr@gmail.com">Editor</a> and/or <a href="http://localhost/sppp/index.php/index/admin/wizard/2/mailto:journaloffice@sumathipublications.com">Journal Office</a>.</p> <p>The journal accepts manuscripts in the following forms:</p> <ul> <li class="show">Original research articles</li> <li class="show">Reviews</li> <li class="show">Case reports</li> <li class="show">Short communications</li> <li class="show">Letters to editor</li> <li class="show">Discussion papers</li> <li class="show">Clinical Experience</li> <li class="show">Clinicopathological correlation Book reviews and</li> <li class="show">"How to do it" type articles describing new methods or procedures.</li> </ul> <p>Kind regards,</p> <p>IJCBR Editorial Team.</p> Sumathi Publications en-US International Journal of Clinical and Biomedical Research 2521-0394 <p>The journal <strong>allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions</strong>.</p> <p>The submitted papers are assumed to contain no proprietary material unprotected by patent or patent application; responsibility for technical content and for protection of proprietary material rests solely with the author(s) and their organizations and is not the responsibility of the journal. The main (first/corresponding) author is responsible for ensuring that the article has been seen and approved by all the other authors. It is the responsibility of the author to obtain all necessary copyright release permissions for the use of any copyrighted materials in the manuscript prior to the submission.</p> <p><strong>What are my rights as an author?</strong><br>It is important to check the policy for the journal to which you are submitting or publishing to establish your rights as<br>Author. Journal's standard policies allow the following re-use rights:</p> <ul> <li class="show">The journal allows the author(s) to hold the copyright without restrictions.</li> <li class="show">The journal allows the author(s) to obtain publishing rights without restrictions.</li> <li class="show">You may do whatever you wish with the version of the article you submitted to the journal.</li> <li class="show">Once the article has been accepted for publication, you may post the accepted version of the article on your own personal website, your department's website or the repository of your institution without any restrictions.</li> <li class="show">You may not post the accepted version of the article in any repository other than those listed above (i.e. you may not deposit in the repository of another institution or a subject-matter repository) until 12 months after publication of the article in the journal.</li> <li class="show">You may use the published article for your own teaching needs or to supply on an individual basis to research colleagues, provided that such supply is not for commercial purposes.</li> </ul> Comparison of electromyographic activity of quadriceps muscle in persons with unilateral traumatic transtibial amputation using patellar tendon bearing supracondylar endoskeletal prosthesis with the unaffected limb in weight bearing positions. https://www.sumathipublications.com/index.php/ijcbr/article/view/402 <p><strong>Abstract</strong></p> <p><strong>Purpose: </strong>comparison of electromyographic activity of quadriceps muscle in persons with unilateral traumatic transtibial amputation using patellar tendon bearing supracondylar endoskeletal prosthesis with the unaffected limb in weight bearing positions.</p> <p><strong>Method: </strong>30 individuals<span class="Apple-converted-space">&nbsp; </span>aged 18-60 years were assessed using surface electromyography with functional level K3 according to K-level functional assessment scale to compare the activity of quadriceps of affected side using patellar tendon bearing supracondylar endoskeletal prosthesis with the unaffected side. The data was analysed using paired t-test.</p> <p><strong>Result</strong>:<span class="Apple-converted-space">&nbsp; </span>There was a significant difference in the activity of VMO and VLO muscles of the quadriceps in high sitting positions. There was also a significant difference in the activity of VMO muscle in single limb stance and bipedal stance. However, there was no significant difference between the activity of VLO muscle in bipedal stance but there was reduced activity of VLO muscle in the prosthetic limb in single limb stance.</p> <p><strong>Conclusion:</strong> The quadriceps activity was reduced in the affected limb in high sitting position, single<span class="Apple-converted-space">&nbsp; </span>limb stance and bipedal stance. However, no difference in the muscle activity was noted in VLO muscle in bipedal stance.</p> <p><strong>Keywords</strong>: <em>trans tibial amputation, patellar tendon bearing supracondylar prosthetis, surface electromyography.<span class="Apple-converted-space">&nbsp;</span></em></p> Dipti Naik Vaibhav Dolas Copyright (c) 2021 Dipti Naik, Vaibhav Dolas http://creativecommons.org/licenses/by-nc-sa/4.0 2021-05-04 2021-05-04 1 5 10.31878/ijcbr.2021.72.01 Myoinositol with Metformin and Myoinositol alone in infertile PCOS women undergoing ovulation induction cycles: A comparative study https://www.sumathipublications.com/index.php/ijcbr/article/view/412 <p>Background: This was a prospective observational study conducted over a twelve-month duration in our institute to compare the combined effect of metformin and myoinositol with metformin alone. Method: A total of sixty patients were included in the study, and they were divided into two groups depending on whether they were given the combination or the single drug. Group A (n=30) was given Myoinositol 600 mg+Metformin 500 mg thrice a day, and Group B ( n=30) was given only Myoinositol 600 mg thrice a day. The outcome measure was clinical pregnancy rate and improvement in clinical and hormonal parameters after drug therapy. Results: BMI (p&lt;0.01), modified Ferriman Gallaway score (p&gt;0.05), and the was a significant improvement in the hormonal parameters (LH,FSH) in both the groups and the levels were found to be comparable after a period of 6 months. The clinical pregnancy rate after six cycles of ovulation was significantly higher in Group A as compared to Group B. In Group A, the total clinical pregnancy rate was 43.33%, and in Group B, it was 26.67%, respectively, and the end of 6 months and the difference was statistically significant (p = &lt;0.01) Conclusion: Equal response in reduction of hormonal levels and clinical and laboratory parameters were seen in both groups, while better results in terms of clinical fertility rates were observed in the group that was given a combination of myoinositol with metformin.</p> Pramod Gade Aher Gautam S Vazifdar Sharmeen Copyright (c) 2021 Pramod Gade, Aher Gautam S, Vazifdar Sharmeen http://creativecommons.org/licenses/by-nc-sa/4.0 2021-05-04 2021-05-04 6 10 10.31878/ijcbr.2021.72.02 Body composition in coronary artery disease in KONKAN region of India-Is non- obesity an indicator of Coronary Artery Disease? https://www.sumathipublications.com/index.php/ijcbr/article/view/399 <p><strong> </strong><strong>Background</strong></p> <p>India is witnessing a rising prevalence of non communicable diseases like diabetes, hypertension, coronary artery disease. This is attributed to rapid nutrition and lifestyle transition taking place since last 2 decades. Obesity is a well known independent risk factor but very little information is available about role of leanness (low BMI). We investigated whether non-obesity could be an independent risk factor for Coronary artery disease in a rural clinic in KONKAN.</p> <p> </p> <p><strong> Methods</strong></p> <p> In a cross sectional study we studied body composition of 300 patients (207 men) who underwent Coronary angiography in a rural hospital in KONKAN region. History of diabetes, hypertension and history smoking, tobacco chewing was recorded. Body composition was estimated using bio-impedance analyser. Based on results of coronary angiography, we generated a SYNTAX score derived by number of vessels involved and classified them into groups of severity of coronary artery disease (CAD). </p> <p> </p> <p><strong>Results</strong></p> <p>There were 95 (31 %) diabetes and 189 (63%) hypertensive patients in the sample and 60% of them smoked or chewed tobacco. There were 43 (28 males) patients with SYNTAX score of zero. Among those with coronary artery disease (n=257) increasing severity of CAD was associated with lower body weight, BMI, body fat percentage, and body fat mass and ejection fraction as against positive trend for lean mass and visceral fat.</p> <p> </p> <p><strong>Conclusion</strong></p> <p>BMI, fat mass decreased with severity of CAD while lean mass and visceral fat increased. We observed high proportion of CAD in underweight and lean KONKAN adults. These findings need further investigations </p> Suvarna Netaji Patil Pranav Shamraj Charudatta Vaman Joglekar Amitkumar Bhalerao Sagar Nanaware Janhavi Deshpande Amey Paranjape Dnyaneshwar Arjun Jadhav Omkar Anant Dervankar Copyright (c) 2021 Suvarna Netaji Patil, Pranav Shamraj, Charudatta Vaman Joglekar, Amitkumar Bhalerao, Sagar Nanaware, Janhavi Deshpande, Amey Paranjape, Dnyaneshwar Arjun Jadhav, Omkar Anant Dervankar http://creativecommons.org/licenses/by-nc-sa/4.0 2021-05-04 2021-05-04 11 15 10.31878/ijcbr.2021.72.03 HYPOMAGNESAEMIA AND HYPOCALCAEMIA THE MAJOR MISSED OUT CLINICAL CONDITION IN THE MANAGEMENT OF DIABETES https://www.sumathipublications.com/index.php/ijcbr/article/view/400 <p>Magnesium (Mg) and Calcium (Ca) is one of the essential factors for the insulin to get released from the pancreatic cell. To evaluate the relation of hypomagnesemia and hypocalcaemia in the glycaemic control and to analyse the importance of both Mg and Ca in the insulin secretion mechanism. The study was conducted in the laboratory department, Billroth hospitals. A total of 239 individuals were selected for this study, HbA1c level, serum magnesium and calcium were assessed for all the individuals and in addition to this serum electrolytes were also checked. Out of 239 individuals, 79 were found out as uncontrolled diabetic by calculating HbA1c as a gold standard, males are higher in ratio compared to female. By studying serum magnesium and calcium level, hypocalcaemia is present in more individuals and females (31%) are much prone to both than males (20%). The different correlation was also analysed for hypomagnesemia and hypocalcaemia. The electrolytes like sodium (Na) and potassium (K) was analysed, females are highly affected by electrolyte imbalance but in hypomagnesemia diabetic individuals the males are high in electrolyte imbalance. Since Mg and Ca plays a vital role in insulin synthesis, secretion, repair, and the alteration, along with the hypoglycaemic agents the supplementation of magnesium or calcium could be suggested via, dietary or drug supplements. In addition to this, regular monitoring of electrolytes is essential to maintain fluid balance.</p> Divya S Fahima Sheerin SMH Chindhiha S Suganthi M Sherafin Vincy Chandrasekar M Dr Selvakumar Kandaswamy Copyright (c) 2021 Divya S, Fahima Sheerin SMH, Chindhiha S, Suganthi M, Sherafin Vincy, Chandrasekar M, Dr Selvakumar Kandaswamy http://creativecommons.org/licenses/by-nc-sa/4.0 2021-05-04 2021-05-04 16 22 10.31878/ijcbr.2021.72.04 Pattern of Acute Organophosphorus Poisoning at a Tertiary Care Hospital of Western Maharashtra https://www.sumathipublications.com/index.php/ijcbr/article/view/413 <p>Background: Every year, 3 million cases of pesticide, mainly O.P. poisoning, occurs all over the world. Therefore, statistics regarding O.P. poisoning in a specific region will aid in the early diagnosis and treatment of cases. The main objective of this research project is to find out the pattern of O.P. poisoning cases at the tertiary care center. Methods: We conducted a retrospective cross-sectional study, in which we analyzed data from 40 cases of O.P. poisoning, including patient information regarding gender, age, time of ingestion, type of poison, mode of poisoning, any first aid received, treatment given, duration of hospital stay and outcome of the treatment. Results: There were 16 females (40%) and 24 males (60%). The most common age group was 21 to 40 years, with 19 participants (47.50%). The majority of the participants were from the rural area, 38 cases (95%), while in 36 cases, the poisoning was suicidal (90%). 28 participants (70%) received some form of first aid. In addition, 21 of the participants received Atropine (52.50%), 13 received only gastric lavage (32.50%), 5 received both Atropine and Pralidoxime (12.50%), while one patient only received Pralidoxime (2.5%) as treatment. I.C.U. admission was required in 39 participants (97.50%), and ventilatory support was required in 2 participants (5%). Our study observed 4 deaths (10%) amongst our participants. The multivariate analysis of deaths in our study showed that specifically not receiving any first aid (p = 0.039) and requirement of the ventilator (p&lt;0.001) were seen to have a significant association with deaths in our study. Conclusion: O.P. poisoning is the commonest cause of suicidal deaths in developing countries. Creating awareness regarding O.P. poisoning and legislative action on using hazardous poisons will help reduce the deaths.</p> Sandeep Sitaram Kadu Shamkumar U Burungale Amrut Arun Swami Copyright (c) 2021 Sandeep Sitaram Kadu, Shamkumar U Burungale, Amrut Arun Swami http://creativecommons.org/licenses/by-nc-sa/4.0 2021-05-04 2021-05-04 23 27 10.31878/ijcbr.2021.72.05 Comparative study of Negative Pressure Wound therapy Vs. Local antibiotic cream dressings in acute hand burns second-degree superficial to deep https://www.sumathipublications.com/index.php/ijcbr/article/view/416 <p>Background: The hand is one of the most common parts of the body involved in burns, i.e., 80%. Even minor burns in the hand may result in severe limitations of function. Early initiation of physiotherapy, topical antibiotic cream treatment, collagen application, splintage, passive exercise for second-degree superficial burns. Materials and methods: A prospective comparative study was conducted in 10 patients with acute hand burns due to thermal burns (scald, flame). All patients with second-degree superficial to intermediate thickness burns were given Negative pressure wound therapy (indigenous NPWT Kit) to one hand and local antibiotic cream to the other hand or other parts of the body to study clinical profile and outcome. Results: A total of 10 patients were studied. The majority of patients were in 19 to 30 years of age group 6 patients (60%), five females, and one male. Pediatric patients account for 4 patients (40%), two female and two male children. Incidence of burns in females 70% and males’ group 30%. Significant reduction in postburn edema in NPWT hand compared to topical antibiotic cream dressing. Healing is fast in NPWT applied hand/part. Conclusion: Negative Pressure Wound Therapy for Acute second-degree superficial burns showed promising results in wound healing and reduced post-burn edema burn in hand in our study.</p> Ganesh Chaudhari Satish Sonawane Copyright (c) 2021 Ganesh Chaudhari, Satish Sonawane http://creativecommons.org/licenses/by-nc-sa/4.0 2021-05-04 2021-05-04 28 32 10.31878/ijcbr.2020.72.06