Total body irradiation in a case of thalassemia major with source to axis distance based planning: A case report

Main Article Content

Mayuresh D. Virkar
Rajkumar Chauhan
Pranav Chadha
Kaustav Talapatra
Reuben Jake Rodrigues
Amrita Shrivastava
Santanu Sen
Sameer Tulpule

Abstract

Background: The use of total body radiation (TBI) before hematopoietic stem cell transplantation (HSCT) would increase the engraftment without transplant-related morbidity or mortality among Thalassemia major (TM) cases. Case presentation: A 2-year-old female child, diagnosed with TM was scheduled for haploidentical allogenic transplant-based protocol, and after that, based on protocol she was scheduled to undergo a single session of TBI as a conditioning regimen before haploidentical allogenic hematopoietic stem cell tranplant. A total dose of 4 Gy was administered.. The incidence of graft failure was reduced as TBI was used before allogeneic stem cell transplantation. TBI provided a uniform dose of radiation to the entire body, penetrating areas such as the central nervous system (CNS) and testes. Conclusion: Total Body Irradiation with the SAD technique is the most effective way of treatment. As it is comfortable for the patient to undergo, easily reproducible, and it helps to achieve a uniform dose distribution.

Keywords
  • Hematopoietic Stem Cell Transplantation; Graft-versus-Host Disease; Thalassemia Minor;,
  • Radiotherapy; Myeloablative conditioning; Haemoglobinopathies

Article Details

How to Cite
Virkar, M., Chauhan, R., Chadha, P., Talapatra, K., Rodrigues, R., Shrivastava, A., Sen, S., & Tulpule, S. (2020). Total body irradiation in a case of thalassemia major with source to axis distance based planning: A case report. International Journal of Clinical and Biomedical Research, 6(4), 25-28. https://doi.org/10.31878/ijcbr.2020.64.06