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Introduction: Heat stress is a major health burden with potential health out-comes. Oxidative stress is a metabolic dysfunction that carries oxidative damage of cells and tissues. Zinc is a co-factor against oxidative stress. Aim: The present study was done to evaluate the Supplementation of zinc in acute and chronic heat stress on antioxidant changes in wistar albino rats. Methodology: 36 Wistar albino rats were selected for the study. They were divided into 2 Groups. Group A was acutely and Group B was chronically heat stressed rats and both were zinc pretreated. The Enzymatic and Non enzyme activity in them were estimated.
Results: After acute and chronic heat stress, i) there was a significant increase (P <0.001) in lipid peroxidation activity. ii) Enzymatic and Non-enzymatic antioxidants were reduced (P < 0.001) iii) Rats pretreated with zinc showed a decrease (P< 0.001) in lipid peroxidation and increase (P < 0.001) in enzymatic antioxidants (P < 0.001) and Non enzymatic antioxidants.
Key Words: antioxidants, heat stress, wistar albino rats
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Albert PC, Chan, Wen Yi. Heat stress and its impacts on occupational health and performance, Indoor and built evnvironment.2016;25 (1) 3-5.
Sapolsky RM, Romero LM, Munck AU. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr. Rev. 2000;21:55-89.
Moberg GP. Biological response to stress: Implication for animal welfare. In: G.P. Moberg and GA Mench. The biology of animal stress.2000;123-146.
King JC, Shames DM, Woodhouse LR. Zinc homeostasis in humans. J Nutr 2000;130: 1360S–6S.
Jackson MJ. Physiology of Zinc: general aspects. In: Mills CF, Editor. Zinc in human biology. London: Springer.1989;1–14.
Fosmire GJ. Zinc toxicity. American Journal of Clinical Nutrition. 1990;51:225–7.
Jackson MJ, Jones DA, Edwards RH. Tissue zinc levels as an index of body zinc status. Clinical Physiology. 1982;2:333–43.
Prasad AS. Clinical, immunological, anti-inflammatory and antioxidant roles of zinc. Experimental Gerontol. 2008; 43: 370–7.
Butterfield DA, Domenico FB. Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain. Biochim. 2014;1824:1693–1706.
Feng B, Ruiz MA. Oxidative-stress-induced epigenetic changes in chronic diabetic complications. Can. J. Physiol. Pharmacol. 2013;91:213–20.
Pisoschi AM, Pop A. The role of antioxidants in the chemistry of oxidative stress: A review. Eur. J. Med. Chem. 2015;97:55–74
Korichneva I. Zinc dynamics in the myocardial redox signaling network. Antioxidant Redox Signal 2006;8:1707–21.
Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979; 95(2):351-8
Marklund S, Marklund G. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase. European Journal of Biochemistry.1974;47: 469-74.
Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Article title. Science, 1973;179:588-90.
Sinha AK. Colorimetric Assay of Catalase. Analytical Biochemistry.1972; 47:389-94.
Omaye ST, Turnbull JD, Sauberlich HE. Selected Methods for the Determination of Ascorbic Acid in Animal Cells, Tissues, and Fluids. Methods in Enzymology.1979;62: 3-11
Desai ID, Vitamin E analysis methods for animal tissues. Methods Enzymol. 1984;105:138-47
Mendoza SP, Capitanio JP, Mason WA. Chronic Social Stress: Studies in Non-human Primates. 2000; 23:227-47
Wang RR, Pan XJ, Peng ZQ. Effects of heat exposure on muscle oxidation and protein functionalities of pectoralis major in broilers. Poultry Science. 2009; 88:1078–84
Günther V, Lindert U. The taste of heavy metals: Gene regulation by MTF-1. Biochem. Biophys. Acta. 2012;1823:1416–25.
Bonaventura P, Benedetti G. Zinc and its role in immunity and inflammation. Autoimmunity Rev. 2015;14:277–85.
Sekler I, Sensi SL. Mechanism and regulation of cellular zinc transport. Molecular Medicine. 2007;13:337–43.