Association between serum uric acid and HbA1c in patients with type 2 diabetes mellitus: A case control study in Indian population

Main Article Content

Indu Verma
Archana Nimesh

Abstract

Background and Aim: Uric acid is a pro-oxidant molecule that might be implicated in increasing oxidative stress and insulin resistance in type 2 diabetes mellitus patients. Hence, the aim of the study was to assess serum uric acid and HbA1c level (an indicator of glycemic control) in these patients and speculate the association between the two.


Methods: 40 newly diagnosed cases of Type 2 diabetes mellitus (20 males and 20 females) with age ranging between 35-70 years were statistically compared against 40 age and sex-matched healthy subjects with respect to their uric acid and HbA1c levels. Demographic data like the height and weight of patients was also recorded and statistically compared.


Results: No statistical difference in age, height and weight were observed in type 2 diabetes cases vs. controls indicating that the groups were comparable. HbA1c and uric acid levels of males and females with type 2 diabetes mellitus were significantly higher in comparison to normal males and females(controls). Correlation analysis showed a positive and significant correlation between HbA1c and uric acid levels in male and female cases of type 2 diabetes mellitus


Conclusion: Uric acid might have a role in the development or worsening of type 2 diabetes mellitus. However, further studies are required with a larger sample size to clearly establish the relationship between uric acid and glycemic control in type 2 diabetes mellitus since studies in the literature have shown conflicting results and hence the understanding of the etiopathogenesis of type 2 diabetes mellitus remains poorly understood with respect to uric acid.


Keywords: type 2 diabetes mellitus; uric acid, HbA1c; etiopathogenesis; correlation.

Article Details

How to Cite
Verma, I., & Nimesh, A. (2020). Association between serum uric acid and HbA1c in patients with type 2 diabetes mellitus: A case control study in Indian population. International Journal of Clinical and Biomedical Research, 6(1), 4-7. https://doi.org/10.31878/ijcbr.2019.61.02

References

International Diabetes Federation. IDF Diabetes Atlas — 7th Edition. Diabetes Atlas http://www. diabetesatlas.org/ (2015)

Holman, N., Young, B. & Gadsby, R. Current prevalence of type 1 and type 2 diabetes in adults and children in the UK. Diabet Med. 32, 1119–1120 (2015).

Bruno, G. et al. Incidence of type 1 and type 2 diabetes in adults aged 30– 49 years: the population based registry in the province of Turin, Italy. Diabetes Care 28, 2613–2619 (2005).

Silva RP, Patricio ES, Bonifacio JPPL, Carvalho LAC, Filho ABC, Miyamoto S, et al. 116 - Pro-Oxidant Effect of Uric Acid Metabolites in Inflammatory Cells. Free Radical Biology and Medicine 2016;100:S60.

Pavithra V, K Revathy and Swaminathan S. Association between Uric acid and HbA1c in type 2 Diabetes Mellitus in Comparison with Controls. Int J Curr Microbiol App Sci 2016;5(4):585- 589

Duman TT, Kocak MZ, Atak BM, Erkus E. Serum Uric acid is correlated with HbA1c levels in type 2 diabetes mellitus.Exp Biomed Res 2018;1(1):6-9

Atak BM, Duman TT, Kocak MZ,Savli H. Serum uric acid level is associated with type 2 diabetes mellitus and diabetic regulation.Exp Biomed Res 2018;1(4):135-139

Takir M, Kostek O, Ozkok A, Elcioglu OC, Bakan A, Erek A, et al. Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia. J Investig Med 2015 Dec;63(8):924-9

Strazzullo P, Puig JG. Uric acid and oxidative stress: relative impact on cardiovascular risk? Nutr Metab Cardiovasc Dis 2007 Jul;17(6):409-14

Su P, Hong L, Zhao Y, Sun H, Li L. Relationship Between Hyperuricemia and Cardiovascular Disease Risk Factors in a Chinese Population: A Cross- Sectional Study. Med Sci Monit 2015 Sep 12;21:2707-17

Osgood K, Krakoff J, Thearle M. Serum uric acid predicts both current and future components of the metabolic syndrome. Metab Syndr Relat Disord 2013 Jun;11(3):157-62

Johnson RJ, Nakagawa T, Jalal D, Sanchez-Lozada LG, Kang DH, Ritz E. Uric acid and chronic kidney disease: which is chasing which? Nephrol Dial Transplant 2013 Sep;28(9):2221-8

Kuwabara M, Hisatome I, Niwa K, Hara S, Roncal-Jimenez CA, Bjornstad P, et al. Uric Acid Is a Strong Risk Marker for Developing Hypertension From Prehypertension: A 5-Year Japanese Cohort Study. Hypertension 2018 Jan;71(1):78-86

Dehghan A, van HM, Sijbrands EJ, Hofman A, Witteman JC. High serum uric acid as a novel risk factor for type 2 diabetes. Diabetes Care 2008 Feb;31(2):361-2.

Chien KL, Chen MF, Hsu HC, Chang WT, Su TC, Lee YT, et al. Plasma uric acid and the risk of type 2 diabetes in a Chinese community. Clin Chem 2008 Feb;54(2):310-6.

Kramer CK, von MD, Jassal SK, Barrett-Connor E. Serum uric acid levels improve prediction of incident type 2 diabetes in individuals with impaired fasting glucose: the Rancho Bernardo Study. Diabetes Care 2009 Jul;32(7):1272-3.

Nakanishi N, Okamoto M, Yoshida H, Matsuo Y, Suzuki K, Tatara K. Serum uric acid and risk for development of hypertension and impaired fasting glucose or Type II diabetes in Japanese male office workers. Eur J Epidemiol 2003;18(6):523-30

Rusdiana, Widjaja SS, Syahputra M, Savira M. Association between Haemoglobin A1c and Uric Acid Levels among Patients with Diabetes Mellitus Type 2 at a Primary Health Care Clinic in North Sumatera, Indonesia. Open Access Maced J Med Sci 2018 Sep 25;6(9):1633-5

Wei F, Chang B, Yang X, Wang Y, Chen L, Li WD. Serum Uric Acid Levels were Dynamically Coupled with Hemoglobin A1c in the Development of Type 2 Diabetes

Cui Y, Bu H, Ma X, Zhao S, Li X, Lu S. The Relation between Serum Uric Acid and HbA1c Is Dependent upon Hyperinsulinemia in Patients with Newly Diagnosed Type 2 Diabetes Mellitus. J Diabetes Res 2016;2016:7184123