ASSOCIATION OF VITAMIN D DEFICIENCY WITH HYPERANDROGENISM IN FEMALES WITH POLYCYSTIC OVARIAN SYNDROME

Abstract

Objective: This study designed to assess the relationship of vitamin D status with clinical features of hyperandrogenism in the young unmarried females Study design: A case control study. The study was carried out in Gynecology and Obstetrics unit of Railway Hospital, Rawalpindi from Oct, 2014 to April, 2015. Materials and Methods: A sample of 100 diagnosed PCOS patients, age range 16-25 years with clinical features of hyperandrogenism were included in this study with their written consent. 25OH Vitamin D Total Elisa Kit was used to assess the levels of Vitamin D. The Data was analyzed by using SPSS version 21 and ANOVA test was used to assess the relationship. P value < 0.05 was considered significant. Results: Vitamin D levels were tested in PCOS patients presenting clinical features of hyperandrogenism and it is found that there is insignificant relationship present between severity of hypovitaminosis D and  hirsutism (P=0.669), acne (P=0.480) and alopecia (P=0.317) among PCOS patients. Conclusion: Although hirsutisim presents itself as the most common feature in PCOS patients (51%), but no significant relationship is found between Hypovitaminosis D and clinical features of hyperandrogenism suggesting insignificant role of vitamin D in the pathogenesis of hyperandrogenism in PCOS patients.

Keywords: Polycystic Ovarian Syndrome; Hyperandrogenism; Vitamin D.