STUDY OF MALONDIALDEHYDE, VITAMIN E AND VITAMIN C LEVELS IN DEPRESSIVE PYSCHAITRIC ILLNESS PATIENTS
Abstract
Background: Incidence of psychomotor and psychiatric illness has promoted an awareness regarding the mental and emotional well-being as an important criterion of health. Research on depression is one of the important researches in psychiatric medicine. Negative reactions to life's situations become repetitively intense and frequent leading to symptoms of depression. Aim: A study on changes between antioxidant levels in cases of depression. Method: It was a Case Control Observational Study. The patients newly diagnosed by psychiatrist & having depression were assessed with Hamilton's depression scale are included in the study. The controls were free from depression. The blood sample was collected from each case and control at fasting. Serum Malondialdehyde (MDA), Serum Tocopherol (Vitamin-E) Serum Ascorbic acid (Vitamin-C) levels were estimated. Result: Category I: Group I, II, III MDA levels were 2.02±0.16, 2.02±0.16, 2.02±0.15 respectively. In Category II: Group I, II, III MDA levels were 6.28±0.77, 5.31±1.33, 5.74±1.13 respectively. Category I: Group I, II, III Vit E levels were 11.27 ± 1.21, 10.99 ± 1.03, 11.44 ± 1.20 respectively. In Category II: Group I, II, III Vit E levels were 9.92 ± 1.14, 10.44 ± 1.35, 10.21 ± 1.30respectively. Category I: Group I, II, III Vit C levels were 0.87 ± 0.06, 0.89 ± 0.14, 0.89 ± 0.06respectively. In Category II: Group I, II, III Vit C levels were 0.82±0.01, 0.82±0.01, 0.82±0.01 respectively. Conclusion: There is a significant difference between mean values of height & weight in Category I and Category II. Thus, the decreased antioxidant levels in depression cases show marked oxidant - antioxidant imbalance with evidence of increased oxidative stress.
KEYWORDS: Psychiatric illness; Serum Malondialdehyde; Serum Tocopherol; Serum ascorbic acid.
Downloads
Downloads
Published
Issue
Section
License
The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.
The submitted papers are assumed to contain no proprietary material unprotected by patent or patent application; responsibility for technical content and for protection of proprietary material rests solely with the author(s) and their organizations and is not the responsibility of the journal. The main (first/corresponding) author is responsible for ensuring that the article has been seen and approved by all the other authors. It is the responsibility of the author to obtain all necessary copyright release permissions for the use of any copyrighted materials in the manuscript prior to the submission.
What are my rights as an author?
It is important to check the policy for the journal to which you are submitting or publishing to establish your rights as
Author. Journal's standard policies allow the following re-use rights:
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to obtain publishing rights without restrictions.
- You may do whatever you wish with the version of the article you submitted to the journal.
- Once the article has been accepted for publication, you may post the accepted version of the article on your own personal website, your department's website or the repository of your institution without any restrictions.
- You may not post the accepted version of the article in any repository other than those listed above (i.e. you may not deposit in the repository of another institution or a subject-matter repository) until 12 months after publication of the article in the journal.
- You may use the published article for your own teaching needs or to supply on an individual basis to research colleagues, provided that such supply is not for commercial purposes.