ACID SENSING ION CHANNELS (ASICS): POTENTIAL TARGETS FOR THE DISCOVERY OF NOVEL THERAPEUTICS IN DISEASE MANAGEMENT

Debendra Nath Roy

Abstract


Acid sensing ion channels (ASIC) are Na+ channels activa ed by ex ernal pro ons. Number of neurological (pa hological pain, expression of fear, anxie y, depression, and neurodegeneration after ischemic s roke e c) and non -neurological (brain umor, cardiovascular mechanosensation, hypoxia induced hyper ension, glaucoma, e c.) disorders are implica ed by various ASICs sub ypes. Due o heir known and po ential roles in many disease pa hologies, i is very au hentic o explore he impor ance of new and selective small molecule inhibi ors and even activa ors of ASICs as a research ool in clinical uses for reating hese diseases pa hogenesis. This review is aimed o find ou he herapeutic po entialities of ASICs arge ed novel drugs in con ex of heir pa hophysiological role in human body. Fluorescen dyes and optical sensors as a means of fas and efficien screening approaches would cer ainly be used o improve he discovery echnology of ASICs modula ed drugs.

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DOI: https://doi.org/10.5455/ijcbr.2018.41.13

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